LT24::Four members of the same family, including three children, have died after the people carrier they were travelling in collided with a heavy goods vehicle on the A40 near Oxford on Monday night.
Thames Valley Police said officers were called at 9.50pm to reports of the collision between a silver Subaru and the HGV near to the railway overbridge just west of Oxford.
Two girls, aged four and eight, a six-year-old boy and a 29-year-old woman were all pronounced dead at the scene, while two other passengers in the Subaru, a 30-year-old man and an 18-month-old girl, were taken to John Radcliffe Hospital in Oxford, where they are in a critical condition.
The family were from Chinnor, in Oxfordshire.
The HGV driver, a 56-year-old man, suffered minor injuries.
Senior investigating officer Sergeant Dominic Mahon, of the Serious Collision Investigation Unit based at Bicester, said the crash was an “absolute tragedy”.
He said: “We are in the very early stages of our investigation into this incredibly tragic incident that has resulted in the deaths of four people from the same family.
“I would appeal to anybody who was driving in the area at the time of the collision and witnessed what happened to please contact 101, or make a report online, quoting reference number 43200321914.
“I would also urge anybody who has dash-cam footage of the incident or either of the vehicles just prior to the incident to please not share this publicly, but contact police with this detail.
“I would ask the public and media to please not speculate as to the cause of this horrendous incident. We will leave no stone unturned to ascertain what has caused this tragedy.
“The next of kin of the family have been made aware and are being supported by specially trained family liaison officers.